PREPARATION OF 2-SUBSTITUTED INDOLE SULFONAMIDES AND SUBSEQUENT CONVERSION TO INDOLE-2-CARBOXYLIC ACIDS, INDOLE-2-CARBONITRILES, AND 2-ACYLINDOLES
PREPARATION OF 2-SUBSTITUTED INDOLE SULFONAMIDES AND SUBSEQUENT CONVERSION TO INDOLE-2-CARBOXYLIC ACIDS, INDOLE-2-CARBONITRILES, AND 2-ACYLINDOLES
复制标题
DOI：
10.1021/jo00796a013
复制
发表时间：
1972-01-01
影响因子：
3.6
通讯作者：
JONES, CD
中科院分区：
文献类型：
--
作者：
JONES, CD
本文介绍了邻氨基酮与卤代酮直接缩合制备2-酰基吲哚的方法。作为本研究的延伸，我们希望讨论使用类似的烷基化-缩合路线2-酰基吲哚，我们已经成功地应用于制备合成更有用的衍生物（即，吲哚-2-羧酸和吲哚-2-碳腈）。
In an accompanying paper, 1 a method was described for the preparation of 2-acylindoles by the direct con-densation of o-amino ketones with-halo ketones. As an extension of this investigation, we wish to discuss the use of an analogous alkylation-condensation route to 2-acylindoles which we have applied successfully to the preparation of synthetically more useful derivatives (ie, indole-2-carboxylic acids and indole-2-carbo-nitriles).