The appearance of bone resorbing activity in ligature induced gingivitis in dogs.
The appearance of bone resorbing activity in ligature induced gingivitis in dogs.
复制标题
结扎线中骨吸收活性的出现诱发了狗的牙龈炎。
DOI：
10.1111/j.1600-0765.1980.tb00294.x
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发表时间：
1980
影响因子：
3.5
通讯作者：
C. Alander
中科院分区：
文献类型：
--
作者：
W. Soskolne;K. Nuki;L. Raisz;C. Alander
比较了来自健康和发炎的狗牙龈的提取物的体外骨吸收活性，并测量了牙龈炎1周和6周之间的吸收因子的出现。使用了7只成年犬。牙龈最初通过刮治和抛光而变得健康。将牙斑固位结扎线放置在牙齿颈部周围，使得在实验结束时，可以从每只狗收获健康牙龈和具有1周龄和6周龄结扎线诱导的牙龈炎的牙龈样品。骨吸收活性的提取物从这些牙龈样品进行了研究，通过测量释放的45钙从预标记的胎鼠长骨在器官培养。健康象限的7种浸提液中有6种没有骨吸收潜力，而结扎象限的14种浸提液中有13种刺激了大量的骨吸收。在结扎放置后的第一周出现再吸收活性，并且在结扎放置后1周和6周获得的浸提液之间未观察到再吸收潜力的显著增加。得出的结论是，骨吸收因子的出现与牙菌斑的积累和/或由此产生的炎症有关，并且它可能是结扎诱导的犬牙周病中观察到的牙槽骨丢失的原因。
The in vitro bone resorbing activity of extracts from healthy and inflamed dog gingiva were compared and the appearance of the resorbing factor between 1 and 6 weeks of gingivitis was measured. Seven adult dogs were used. The gingiva were initially rendered healthy by scaling and polishing. Plaque retentive ligatures were placed around the necks of teeth so that at the end of the experiment samples of healthy gingiva and gingiva with 1 and 6 week old ligature induced gingivitis could be harvested from each dog. The bone resorbing activity of extracts from these gingival samples was studied by measuring the release of 45Ca from prelabeled fetal rat long bones in organ culture. Six out of 7 extracts from healthy quadrants had no bone resorbing potential whereas 13 out of 14 extracts from ligatured quadrants stimulated significant amounts of bone resorption. The resorbing activity appeared during the first week after ligature placement and no significant increase in resorbing potential was noted between extracts obtained 1 and 6 weeks after ligature placement. It was concluded that the appearance of the bone resorbing factor(s) is related to the accumulation of plaque and/or the resultant inflammation and that it may be responsible for the alveolar bone loss seen in ligature induced periodontal disease in dogs.