Vascular Smooth Muscle Cell Remodeling.
Vascular Smooth Muscle Cell Remodeling.
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DOI：
10.1161/circresaha.118.314184
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发表时间：
2018-12
影响因子：
20.1
通讯作者：
J. Fiedler;T. Thum
中科院分区：
文献类型：
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作者：
J. Fiedler;T. Thum
除了众所周知的蛋白质编码基因组的贡献外，非编码 RNA (ncRNA) 转录本也被发现在血管生物学中具有多效性。异质类 ncRNA 包括 microRNA（约 20 个核苷酸）、长 ncRNA（lncRNA；>200 个核苷酸）和环状 lncRNA（即所谓的环状 RNA）等成员。实验表明，ncRNA 在血管平滑肌细胞 (vSMC) 特征的建立中发挥着强大的作用。对单个 miR 簇（例如 miR-143/145）的初步研究证明，小 ncRNA 在 vSMC 分化中具有调节功能。随后的工作表明，vSMC 中表达的 miRNA 有助于控制血管稳态和血压，并且 miR-24 在 vSMC 表型的发展中发挥作用。
Besides contribution of the well-understood protein-encoding genome, noncoding RNA (ncRNA) transcripts have been discovered for pleiotropic aspects in vascular biology. The heterogenous class of ncRNA comprises members such as microRNAs (≈20 nucleotides), long ncRNAs (lncRNAs; >200 nucleotides), and circularized lncRNAs, so-called circular RNAs. Experiments have shown that ncRNAs play powerful roles in the establishment of the features of vascular smooth muscle cell (vSMC). Initial studies of single miR clusters, such as miR-143/145, proved that small ncRNAs have regulatory functions in vSMC differentiation. Subsequent work indicated that miRNAs expressed in vSMCs contributed to the control of vascular homeostasis and blood pressure and that miR-24 played a role in the development of the vSMC phenotype.