The effect of protein degradation on cellular growth characteristics
The effect of protein degradation on cellular growth characteristics
复制标题
蛋白质降解对细胞生长特性的影响
DOI：
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发表时间：
1978
影响因子：
5.6
通讯作者：
C. Stanners
中科院分区：
文献类型：
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作者：
G. C. Baxter;C. Stanners
通过测量不同细胞类型在不同生长条件下不稳定和稳定蛋白质的降解率，研究了蛋白质降解在细胞增殖中的作用。蛋白质降解速率是一个相对不变的参数，因为在环己亚胺或组氨醇强烈抑制蛋白质合成后，蛋白质降解速率没有变化，在指数相和稳定期都是相同的，并且它与有无恶性转化无关。
The role of protein degradation in cellular proliferation was investigated by measurements of the rates of degradation of labile and stable proteins for a number of cell types under various growth conditions. The rate of protein degradation was found to be a relatively invariant parameter in that it did not change after strong inhibition of protein synthesis with cycloheximide or histidinol, it was the same in both exponential and stationary phase, and it did not correlate with the presence or absence of malignant tranformation.