IMPAIRED LEARNING AND DECREASED CORTICAL NOREPINEPHRINE AFTER BILATERAL LOCUS COERULEUS LESIONS
IMPAIRED LEARNING AND DECREASED CORTICAL NOREPINEPHRINE AFTER BILATERAL LOCUS COERULEUS LESIONS
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DOI：
10.1126/science.181.4100.682
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发表时间：
1973-01-01
期刊：
影响因子：
56.9
通讯作者：
GREENWAY, AP
中科院分区：
文献类型：
--
作者：
ANLEZARK, GM;CROW, TJ;GREENWAY, AP
大鼠双侧蓝斑核损伤导致大脑皮层去甲肾上腺素的消耗，并显著降低了在简单l型跑道上跑取食物奖励的增加速率。在这种情况下，尽管这些大鼠表现出正常的体重增加和正常的运动和探索活动，但蓝斑最完全消融的大鼠却没有学习能力。
Bilateral lesions of the nucleus locus coeruleus in rats deplete the cerebral cortex of norepinephrine and significantly diminish the rate of increase of running for food reward in a simple L-shaped runway. As assessed in this situation, learning was absent in those rats with the most complete ablations of the locus coeruleus, although these rats showed normal weight gain and normal motor and exploratory activity.