Is bipolar disorder specifically associated with panic disorder in youths?
Is bipolar disorder specifically associated with panic disorder in youths?
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DOI：
10.4088/jcp.v63n0507
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发表时间：
2002-05-01
影响因子：
5.3
通讯作者：
Axelson, D
中科院分区：
文献类型：
--
作者：
Birmaher, B;Kennah, A;Axelson, D
目的：复制以前的调查结果的高利率双相情感障碍（BPD）的患者惊恐障碍（PD），并确定是否与PD和BPD的青年有更严重的illustration.Method：2025年的青少年年龄在5至19岁的情绪和焦虑专科诊所进行了评估，使用时间表情感障碍和精神分裂症的学龄儿童目前发作。第四次修订。诊断采用DSM-III和DSM-III-R标准，然后更新以符合DSM-IV标准。将患者分为PD患者（N = 42）和非PD焦虑障碍患者（N = 407）。结果：青少年PD患者共患BPD的可能性（N = 8，19.0%）高于青少年非PD焦虑障碍（N = 22，5.4%）或其他非焦虑性精神障碍（N = 112，7.1%）。PD与BPD共病对PD和躁狂症状无影响。与PD和BPD的青年有更多的精神病症状和自杀意念比PD和其他非双相情感障碍和BPD患者与其他nonanxious comorbid disorders.Conclusion：PD或BPD在青年的存在下，其他条件的共同发生更有可能，已注意到在成年人。同时患有PD和BPD的患者更容易出现精神病性症状和自杀意念。在治疗青少年PD时，临床医生必须警惕可能的共病BPD或药物触发躁狂或轻躁狂发作的风险。需要进行前瞻性研究，以了解PD是否可预测儿童和青少年BPD的发病。
Objective: To replicate previous findings of high rates of bipolar disorder (BPD) in patients with panic disorder (PD) and determine if youths with both PD and BPD have more severe illness.Method: 2025 youths aged 5 to 19 years seen at a mood and anxiety specialty clinic were assessed using the Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present Episode. 4th Revision. Diagnoses were made using DSM-III and DSM-III-R criteria and then updated to conform to DSM-IV criteria. Patients were grouped into those with PD (N = 42), those with non-PD anxiety disorders (N = 407). and psychiatric controls with no anxiety diagnosis (N = 1576).Results: Youths with PD were more likely to exhibit comorbid BPD (N = 8, 19.0%) than youths with either non-PD anxiety disorders (N = 22, 5.4%) or other nonanxious psychiatric disorders (N = 112, 7.1%). The symptoms of PD and mania were not affected by the comorbidity between PD and BPD. Youths with both PD and BPD had more psychotic symptoms and suicidal ideation than patients with PD and other non-bipolar psychiatric disorders and BPD patients with other nonanxious comorbid disorders.Conclusion: The presence of either PD or BPD in youths made the co-occurrence of the other condition more likely, as has been noted in adults. Patients with both PD and BPD are more likely to ha e psychotic symptoms and suicidal ideation. In treating youths with PD, clinicians must be vigilant for possible comorbid BPD or risk of pharmacologic triggering of a manic or hypomanic episode. Prospective studies are needed to learn if PD predicts the onset of BPD in children and adolescents.