Decomposition of Iodinated Pharmaceuticals by UV-254 nm-assisted Advanced Oxidation Processes
Decomposition of Iodinated Pharmaceuticals by UV-254 nm-assisted Advanced Oxidation Processes
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DOI：
10.1016/j.jhazmat.2016.04.022
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发表时间：
2017-02-05
影响因子：
13.6
通讯作者：
Dionysiou, Dionysios D.
中科院分区：
文献类型：
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作者：
Duan, Xiaodi;He, Xuexiang;Dionysiou, Dionysios D.
碘化药物，甲状腺素（一种甲状腺激素）和泛影葡胺（一种碘化X射线造影剂），是最常用的活性药物成分。据报道，即使在非常低的浓度下，这两种药物也可能破坏甲状腺稳态。在这项研究中，基于UV 254 nm的光解和光化学过程，即，评价了仅UV、UV/H2 O2和UV/S2 O 82-对这两种药物的破坏作用。大约40%的0.5 μ M甲状腺素或泛影葡胺在160 mJ cm（-2）的UV能量密度下通过直接光解降解，可能是由于C-I键的光敏断裂。虽然H2 O2的加入仅在很低程度上加速了降解效率，但在UV/S2 O 82-系统中，两种化学品的破坏率均显著增强，表明碘化化学品对UV/S2 O 82-处理的潜在脆弱性。这种有效的破坏也发生在自由基清除剂的存在下，当生物处理的废水样品被用作反应基质。初始氧化剂浓度的影响，溶液的pH值，以及存在的天然有机物（腐殖酸或富里酸）和碱度也进行了研究。这些结果提供了见解的去除碘化药物在水和/或废水中使用基于UV的光化学过程。(C)© 2016 Elsevier B. V.版权所有。
Iodinated pharmaceuticals, thyroxine (a thyroid hormone) and diatrizoate (an iodinated X-ray contrast medium), are among the most prescribed active pharmaceutical ingredients. Both of them have been reported to potentially disrupt thyroid homeostasis even at very low concentrations. In this study, UV 254 nm-based photolysis and photochemical processes, i.e., UV only, UV/H2O2, and UV/S2O82-, were evaluated for the destruction of these two pharmaceuticals. Approximately 40% of 0.5 mu M thyroxine or diatrizoate was degraded through direct photolysis at UV fluence of 160 mJ cm(-2), probably resulting from the photosensitive cleavage of C-I bonds. While the addition of H2O2 only accelerated the degradation efficiency to a low degree, the destruction rates of both chemicals were significantly enhanced in the UV/S2O82- system, suggesting the potential vulnerability of the iodinated chemicals toward UV/S2O82- treatment. Such efficient destruction also occurred in the presence of radical scavengers when biologically treated wastewater samples were used as reaction matrices. The effects of initial oxidant concentrations,solution pH, as well as the presence of natural organic matter (humic acid or fulvic acid) and alkalinity were also investigated in this study. These results provide insights for the removal of iodinated pharmaceuticals in water and/or wastewater using UV-based photochemical processes. (C) 2016 Elsevier B.V. All rights reserved.