Differential role of angiogenesis and tumour cell proliferation in brain metastases according to primary tumour type: analysis of 639 cases
Differential role of angiogenesis and tumour cell proliferation in brain metastases according to primary tumour type: analysis of 639 cases
复制标题
DOI：
10.1111/nan.12185
复制
发表时间：
2015-02-01
影响因子：
5
通讯作者：
Preusser, M.
中科院分区：
文献类型：
--
作者：
Berghoff, A. S.;Ilhan-Mutlu, A.;Preusser, M.
目的我们旨在表征大型脑转移瘤（BM）系列中的血管生成和增殖及其与临床特征的相关性。方法采用免疫组化法测定BM和原发肿瘤标本中的Ki67增殖指数、微血管密度（MVD）和缺氧诱导因子1α（HIF-1α）指数。结果639例肺癌患者的639个BM标本（344/639; 53.8%）、乳腺癌（105/639；16.4%）、黑色素瘤（67/639；10.5%）、肾细胞癌（RCC；52/639；8.1%）或结直肠癌（CRC；71/639；11.1%）。 113/639 (17.7%) 例中可获得相应原发肿瘤的标本。中位 Ki67 指数在 CRC BM 中最高，在 RCC BM 中最低（P
AimWe aimed to characterize angiogenesis and proliferation and their correlation with clinical characteristics in a large brain metastasis (BM) series.MethodsKi67 proliferation index, microvascular density (MVD) and hypoxia-inducible factor 1 alpha (HIF-1 alpha) index were determined by immunohistochemistry in BM and primary tumour specimens.ResultsSix hundred thirty-nine BM specimens of 639 patients with lung cancer (344/639; 53.8%), breast cancer (105/639; 16.4%), melanoma (67/639; 10.5%), renal cell carcinoma (RCC; 52/639; 8.1%) or colorectal cancer (CRC; 71/639; 11.1%) were available. Specimens of the corresponding primary tumour were available in 113/639 (17.7%) cases. Median Ki67 index was highest in CRC BM and lowest in RCC BM (P