Role of lateral amygdala calstabin2 in regulation of fear memory
Role of lateral amygdala calstabin2 in regulation of fear memory
复制标题
外侧杏仁核calstabin2在恐惧记忆调节中的作用
DOI：
10.1186/s13041-020-00576-7
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发表时间：
2020-03-09
期刊：
影响因子：
3.6
通讯作者：
Xin, Hong-bo
中科院分区：
文献类型：
--
作者：
Han, Ren-wen;Liu, Zhi-peng;Xin, Hong-bo
Calstabin2，也被称为FK506结合蛋白12.6 (FKBP12.6)，是ryanodine受体亚型2 （RyR2）大分子复合物的一个亚基，是细胞内钙通道。我们和其他实验室的研究表明，海马体calstabin2调节空间记忆。钙稳定蛋白2和RyR2广泛分布在大脑中，包括杏仁核，这是一个关键的大脑区域，参与调节包括恐惧在内的情绪。人们对钙稳定蛋白2在恐惧记忆中的作用知之甚少。本研究发现，在暗含恐惧条件反射实验中，calstabin2基因缺失会导致长期记忆受损。病毒载体敲除外侧杏仁核（LA）中的钙稳定蛋白2也会损害长期线索恐惧记忆的表达。此外，钙稳定蛋白2敲除减少了皮层和丘脑输入LA的长期增强（LTP）。综上所述，我们目前的数据表明LA中的calstabin2在情绪记忆的调节中起着至关重要的作用。
Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, an intracellular calcium channel. Studies from our and other's lab have shown that hippocampal calstabin2 regulates spatial memory. Calstabin2 and RyR2 are widely distributed in the brain, including the amygdala, a key brain area involved in the regulation of emotion including fear. Little is known about the role of calstabin2 in fear memory. Here, we found that genetic deletion of calstabin2 impaired long-term memory in cued fear conditioning test. Knockdown calstabin2 in the lateral amygdala (LA) by viral vector also impaired long-term cued fear memory expression. Furthermore, calstabin2 knockout reduced long-term potentiation (LTP) at both cortical and thalamic inputs to the LA. In conclusion, our present data indicate that calstabin2 in the LA plays a crucial role in the regulating of emotional memory.