Potential role of high mobility group box 1 in viral infectious diseases.
Potential role of high mobility group box 1 in viral infectious diseases.
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高迁移率族盒 1 在病毒感染性疾病中的潜在作用。
DOI：
10.1089/vim.2006.19.3
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发表时间：
2006
期刊：
影响因子：
2.2
通讯作者：
Li,Wei
中科院分区：
文献类型：
--
作者：
Wang,Haichao;Ward,MaryF;Fan,Xue-Gong;Sama,AndrewE;Li,Wei
一种核蛋白，高迁移率族蛋白1（HMGB 1），由坏死细胞被动释放，并由巨噬细胞/单核细胞主动释放，以响应外源性和内源性炎症刺激。HMGB 1与晚期糖基化终末产物受体（RECEPTOR）或Toll样受体4（TLR 4）结合后，激活巨噬细胞/单核细胞表达促炎细胞因子、趋化因子和粘附分子。其活性或释放的药理学抑制是对致死性内毒素血症和脓毒症的保护，建立HMGB 1作为致死性全身炎症的关键介质。根据观察，许多病毒（例如，西尼罗河病毒、鲑鱼贫血病毒）可以诱导HMGB 1被动释放，我们提出HMGB 1在病毒性传染病中的潜在致病作用。
A nuclear protein, high mobility group box 1 (HMGB1), is released passively by necrotic cells and actively by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli. After binding to the receptor for advanced glycation end products (RAGE), or Toll-like receptor 4 (TLR4), HMGB1 activates macrophages/monocytes to express proinflammatory cytokines, chemokines, and adhesion molecules. Pharmacological suppression of its activities or release is protective against lethal endotoxemia and sepsis, establishing HMGB1 as a critical mediator of lethal systemic inflammation. In light of observations that many viruses (e.g., West Nile virus, Salmon anemia virus) can induce passive HMGB1 release, we propose a potential pathogenic role of HMGB1 in viral infectious diseases.