Role of estrogen in angiogenesis in cardiovascular diseases.
Role of estrogen in angiogenesis in cardiovascular diseases.
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DOI：
10.3969/j.issn.1671-5411.2013.04.008
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Gao XM
中科院分区：
文献类型：
--
作者：
Barnabas O;Wang H;Gao XM
新血管的形成是血管生成的一个重要过程，也是血管系统中最有效的过程。缺氧诱导因子等参与损伤组织再生的生理过程在内皮中的血管系统中是不同的，并且由于一些主要的血管生成生长因子如血管内皮生长因子、成纤维细胞生长因子和表皮生长因子等导致细胞血管再生的因素而受到限制。这些导致细胞血管再生的生理过程可能是治疗心血管疾病（如缺血和动脉粥样硬化）的主要功能。雌激素是细胞机制中已知的因素之一，可以启动受损血管组织的修复，因为雌激素是血管生成的已知诱导剂，导致细胞再生。研究还表明，这种细胞再生是由血管新生生长因子通过雌激素受体诱导的。在这篇综述中，我们将试图总结在这些生理过程中参与血管生成的主要生长因子和可能导致这种血管再生的新机制。同时，我们将尝试总结一些关于雌激素在导致心血管疾病血管生成的生理过程中的作用的报道。
The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases.
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影响因子：
9.3
作者：
Deschamps, Anne M.;Murphy, Elizabeth;Sun, Junhui
通讯作者：
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37.3
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37.8
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4.8
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影响因子：
3.7
作者：
Chakrabarti S;Davidge ST
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