Brain Organoids and the Study of Neurodevelopment.
Brain Organoids and the Study of Neurodevelopment.
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DOI：
10.1016/j.molmed.2018.09.005
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发表时间：
2018-12
影响因子：
13.6
通讯作者：
Muotri AR
中科院分区：
文献类型：
--
作者：
Trujillo CA;Muotri AR
脑类器官是由数十万至数百万个细胞组成的三维自组装结构，类似于发育中的人脑的细胞组织，转录和表观遗传特征。使用脑类器官的进展已经阐明了某些神经发育障碍的遗传基础，如小头畸形和自闭症;并调查环境因素对大脑的影响，如寨卡病毒感染期间。大脑类器官在功能上成熟和处理外部信息的程度还有待探索。一个改进的脑类器官模型可能会以更可重复和高通量的方式再现人脑的重要方面。神经科学工具箱中的这种新颖和互补的方法打开了理解人类神经发育基本特征的视角，并对神经系统疾病的个性化治疗机会产生了影响。
Brain organoids are three-dimensional self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization, transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to elucidate the genetic basis of certain neurodevelopmental disorders, such as microcephaly and autism; and to investigate the impact of environmental factors to the brain, such as during Zika infection. It remains to be explored how far brain organoids can functionally mature and process external information. An improved brain organoid model might reproduce important aspects of the human brain in a more reproducible and high-throughput fashion. This novel and complementary approach in the neuroscience toolbox opens perspectives to understand the fundamental features of the human neurodevelopment, with implications to personalize therapeutic opportunities for neurological disorders.
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