Improving precision functional mapping routines with multi-echo fMRI.
Improving precision functional mapping routines with multi-echo fMRI.
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DOI：
10.1016/j.cobeha.2021.03.017
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发表时间：
2021-08
影响因子：
5
通讯作者：
Liston C
中科院分区：
文献类型：
--
作者：
Lynch CJ;Elbau I;Liston C
快速发展的方法来获取和分析密集采样，单一主题的功能磁共振成像数据开辟了新的途径，了解个体行为差异的神经生物学基础，并可能使功能磁共振成像成为一个更临床有用的工具。在这里，我们简要回顾了这些精确功能映射研究的关键见解，并强调了其临床翻译的重大障碍。具体来说，可靠地描绘人类个体的功能性大脑网络可能需要每个受试者数小时的静息状态fMRI数据。我们最近发现，多回波功能磁共振成像提高了静息状态功能连接测量的重测信度，减轻了获取大量个体数据的需要。由于多回波采集的优势在临床重要但易出现伪影的大脑区域（如膝下扣带回和皮层下深处的结构）中最为明显，因此该方法有可能增加精确功能标测例程在健康人群和临床人群中的影响。
Rapidly developing approaches to acquiring and analyzing densely-sampled, single-subject fMRI data have opened new avenues for understanding the neurobiological basis of individual differences in behavior and could allow fMRI to become a more clinically useful tool. Here, we review briefly key insights from these precision functional mapping studies and a highlight significant barrier to their clinical translation. Specifically, that reliable delineation of functional brain networks in individual humans can require hours of resting-state fMRI data per-subject. We found recently that multi-echo fMRI improves the test-retest reliability of resting-state functional connectivity measurements, mitigating the need for acquiring large quantities of per -subject data. Because the benefits of multi-echo acquisitions are most pronounced in clinically important but artifact-prone brain regions, such as the subgenual cingulate and structures deep in the subcortex, this approach has the potential to increase the impact of precision functional mapping routines in both healthy and clinical populations.
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