No overt cellular inflammation around intravascular schistosomes in vivo
No overt cellular inflammation around intravascular schistosomes in vivo
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DOI：
10.1645/ge-864r.1
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发表时间：
2006-12-01
影响因子：
1.3
通讯作者：
Skelly, Patrick J.
中科院分区：
文献类型：
--
作者：
Keating, John H.;Wilson, R. Alan;Skelly, Patrick J.
血吸虫是一种血管内的扁平蠕虫寄生虫，在血流中暴露于宿主免疫效应物。抗体依赖性细胞介导的细胞毒作用（antibody-dependentcell-mediatedcytotoxicity，ADCC）在体外可杀死寄生虫，被认为是体内抗虫免疫的重要机制之一。在这项研究中，我们检查了部分成年曼氏血吸虫在原位，血管内的菌株的小鼠表现出低（Balb/c）或高（CBA）病理，并在血管感染的黑猩猩，周围的蠕虫细胞炎症的证据。在这两种小鼠品系中，我们观察到肠道和肝脏组织中寄生虫卵周围的强烈细胞炎症。然而，我们在体内成熟寄生虫周围没有检测到明显的细胞炎症。同样，在受感染的黑猩猩的脉管系统中，在原位成年黑猩猩小体周围没有检测到免疫细胞积聚。这些数据表明，寄生虫可以促进针对卵的极性免疫反应（并帮助卵离开宿主并继续生命周期），但不能有效地针对这些卵的来源，即蠕虫。
Schistosomes are intravascular platyhelminth parasites that are exposed in the blood stream to host immunological effectors. Antibody-dependent cell-mediated cytotoxicity (ADCC) can act in vitro to kill the parasites, and this has been proposed as one important mechanism of antiworm immunity in vivo. In this study, we examined sections of adult Schistosoma mansoni in situ, within the vasculature of strains of mice that exhibit low (Balb/c) or high (CBA) pathology, and in the vasculature of infected chimpanzees, for evidence of cellular inflammation around the worms. In both mouse strains, we observe robust cellular inflammation around the parasite eggs in the intestines and liver tissue. However, we detect no overt cellular inflammation around the mature parasites in vivo. Likewise in the vasculature of infected chimpanzees, no immune cell accumulations are detected around adult schistosomes in situ. These data suggest that the parasites can promote a polar immune response that targets eggs (and assists the eggs to exit the host and continue the life cycle) but that does not effectively target the source of those eggs, namely, the adult worms.