The gut-microbiota-brain axis: An introduction to a special issue on its role in neurological disorders.
The gut-microbiota-brain axis: An introduction to a special issue on its role in neurological disorders.
复制标题
肠道-微生物群-大脑轴：介绍其在神经系统疾病中的作用的特刊。
DOI：
10.1111/ene.16080
复制
发表时间：
2023
影响因子：
5.1
通讯作者：
De Looze K
中科院分区：
文献类型：
--
作者：
De Looze K
肠道微生物群是胃肠道中存在的复杂微生物生态系统。肠道微生物群的组成和功能由多种因素决定，例如年龄、环境因素（例如饮食、抗生素使用、压力）以及较小程度的宿主遗传学[1]。宿主与微生物群的相互作用对于正常宿主生理、代谢和免疫至关重要[2]。肠道菌群平衡的破坏可能会影响局部和远端的器官系统。越来越多的证据表明肠道微生物群和中枢神经系统之间存在复杂的双向通讯[3]。这种双向通讯联系被命名为肠道-微生物群-大脑轴。肠道菌群失调与帕金森病、自闭症谱系障碍、多发性硬化症、抑郁症和癫痫等多种中枢神经系统（CNS）疾病之间的联系目前正在深入研究[4]。
The gut microbiota is a complex ecosystem of microorganisms present in the gastrointestinal tract. The composition and functioning of the intestinal microbiota are determined by multiple factors such as age, environmental factors such as diet, antibiotic use, stress, and to a lesser extent host genetics [1]. The host–microbiota interaction is crucial for normal host physiology, metabolism, and immunity [2]. Disruption of the balanced intestinal flora may impact local, but also remote organ systems. There is a growing body of evidence suggesting a complex, bidirectional communication between the gut microbiota and the central nervous system [3]. This two-way communication link has been named the gut–microbiota–brain axis. The connection between intestinal dysbiosis and a broad range of central nervous system (CNS) disorders such as Parkinson disease, autism spectrum disorder, multiple sclerosis, depression, and epilepsy is currently being studied intensively [4].