Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran
Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran
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DOI：
10.1186/s12879-020-05128-x
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发表时间：
2020-06-18
影响因子：
3.7
通讯作者：
Moghadami, Mohsen
中科院分区：
文献类型：
--
作者：
Shahriarirad, Reza;Khodamoradi, Zohre;Moghadami, Mohsen
背景2020年3月，世界卫生组织宣布新型冠状病毒(新冠肺炎)爆发为全球大流行。虽然感染病例的数量在增加，但在中东，特别是被认为是世界上最重要的疫情中心之一的伊朗，缺乏关于其临床特征的信息。到目前为止，还没有关于伊朗新冠肺炎患者临床数据的文献。方法采用多中心回顾性研究方法，将2月20日至3月20日在伊朗设拉子大学附属医院住院确诊的113例新冠肺炎患者作为研究对象。结果平均年龄53.75岁，男性71例(62.8%)。起病时最常见的症状是乏力(75：66.4%)、咳嗽(73：64.6%)和发热(67：59.3%)。实验室资料显示淋巴细胞计数(P值=0.003)、部分凝血活酶时间(P值=0.000)、国际标准化比率(P值=0.000)与病情严重程度显著相关。胸部CT最常见的异常是磨玻璃样阴影(77：93.9%)，其次是实变(48：58.5%)。我们的结果显示，患者中总的死亡率为8%(9/113例)，其中大部分是住进ICU的患者(5：55.6%)。结论对新冠肺炎患者的临床资料进行评估，找出感染源，研究其发病行为，对了解疫情的发生具有重要意义。
Background In March 2020, the WHO declared the novel coronavirus (COVID-19) outbreak a global pandemic. Although the number of infected cases is increasing, information about its clinical characteristics in the Middle East, especially in Iran, a country which is considered to be one of the most important focal points of the disease in the world, is lacking. To date, there is no available literature on the clinical data on COVID-19 patients in Iran. Methods In this multicenter retrospective study, 113 hospitalized confirmed cases of COVID-19 admitted to university affiliated hospitals in Shiraz, Iran from February 20 to March 20 were entered in the study. Results The mean age was 53.75 years and 71 (62.8%) were males. The most common symptoms at onset were fatigue (75: 66.4%), cough (73: 64.6%), and fever (67: 59.3%). Laboratory data revealed significant correlation between lymphocyte count (Pvalue = 0.003), partial thromboplastin time (Pvalue = 0.000), international normalized ratio (P value = 0.000) with the severity of the disease. The most common abnormality in chest CT scans was ground-glass opacity (77: 93.9%), followed by consolidation (48: 58.5%). Our results revealed an overall 8% (9 out of 113 cases) mortality rate among patients, in which the majority was among patients admitted to the ICU (5: 55.6%). Conclusion Evaluating the clinical data of COVID-19 patients and finding the source of infection and studying the behavior of the disease is crucial for understanding the pandemic.