Acute myeloid leukemia in the elderly: do we know who should be treated and how?
Acute myeloid leukemia in the elderly: do we know who should be treated and how?
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DOI：
10.3109/10428194.2013.828348
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发表时间：
2014-05
影响因子：
2.6
通讯作者：
Ravandi F
中科院分区：
文献类型：
--
作者：
Nazha A;Ravandi F
与年轻患者相比，老年急性髓性白血病（AML）与几个独特的生物学和临床特征相关。尽管在支持性治疗方面取得了进展，并引入了强度较低的化疗方案，但该人群的总体结局仍然较差。更重要的是，根据患者的合并症和疾病的生物学特征，为个体患者选择适当治疗的决策过程仍然是治疗医生面临的挑战。目前，大量老年AML患者没有接受支持性治疗以外的治疗;一些研究表明，接受任何治疗的患者比仅接受姑息治疗的患者结局更好。此外，新的、靶向的、强度较低的治疗方法的开发为具有多种合并症和高风险疾病特征的老年患者提供了新的选择。在这篇综述中，我们将强调治疗医生遇到老年AML患者时所面临的挑战，并将描述一些正在开发的治疗老年AML患者的潜在策略和最近临床试验的可用数据。
Acute myeloid leukemia (AML) in the elderly is associated with several distinctive biological and clinical features compared to younger patients. Despite the advances in supportive care and the introduction of less intensive chemotherapy regimens, the overall outcome for this population remains poor. More importantly, the decision making process for choosing the appropriate treatment for individual patient, based on their comorbidities and the biological features of their disease, continues to be challenging for the treating physicians. Currently, a significant number of elderly patients with AML do not receive treatment above and beyond supportive care; several studies have suggested that patients who receive any therapy have a better outcome than patients who receive palliation alone. Furthermore, the development of novel, targeted, and less intensive therapies is providing new options suitable for older patients with multiple comorbidities and with high risk disease features. In this review, we will highlight the challenges that face the treating physicians when encountering elderly patients with AML and will describe some of the potential strategies under development for treating older AML patients and the available data from recent clinical trials.
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影响因子：
6.2
作者：
Faderl S;Ravandi F;Huang X;Wang X;Jabbour E;Garcia-Manero G;Kadia T;Ferrajoli A;Konopleva M;Borthakur G;Burger J;Feliu J;Kantarjian HM
通讯作者：
Kantarjian HM
影响因子：
6.5
作者：
Giles, Francis J.;Borthakur, Gautam;Kantarjian, Hagop
通讯作者：
Kantarjian, Hagop
影响因子：
6.2
作者：
Burnett, Alan K.;Milligan, Donald;Wheatley, Keith
通讯作者：
Wheatley, Keith
影响因子：
20.3
作者：
Harousseau, Jean-Luc;Martinelli, Giovanni;Howes, Angela J.
通讯作者：
Howes, Angela J.
影响因子：
20.3
作者：
Estey, EH;Thall, PF;Kantarjian, HM
通讯作者：
Kantarjian, HM