Satiety threshold during maintained cocaine self-administration in outbred mice.
Satiety threshold during maintained cocaine self-administration in outbred mice.
复制标题
近交系小鼠维持可卡因自我给药期间的饱腹感阈值。
DOI：
10.1097/00001756-200102120-00029
复制
发表时间：
2001
期刊：
影响因子：
1.7
通讯作者：
Norman,AB
中科院分区：
文献类型：
--
作者：
Tsibulsky,VL;Norman,AB
Male Swiss Webster mice maintained cocaine self-administration in a regular and dose-dependent manner. These characteristics made it possible to apply the satiety threshold model of drug self-administration developed recently for cocaine self-administration in rats. Non-linear regression analysis revealed that cocaine satiety threshold was 1.3±0.6 mg/kg and the functional half-life of the cocaine was 8.1±2.2 min. Whether the self-administration of cocaine was maintained by lever presses or nose pokes did not influence the inter-injection intervals. The results are consistent with the pharmacological model of maintained cocaine self-administration. The ability to determine addiction-relevant phenotypes (the satiety threshold and functional half-life of cocaine) in inbred strains of mice may help to identify the genetic determinants of cocaine self-administration behavior.
