SYMPTOMS AND RISK-FACTORS OF HELICOBACTER-PYLORI INFECTION IN A COHORT OF EPIDEMIOLOGISTS
SYMPTOMS AND RISK-FACTORS OF HELICOBACTER-PYLORI INFECTION IN A COHORT OF EPIDEMIOLOGISTS
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DOI：
10.1016/0016-5085(92)91782-y
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发表时间：
1992-01-01
期刊：
影响因子：
29.4
通讯作者：
TAUXE, RV
中科院分区：
文献类型：
--
作者：
PARSONNET, J;BLASER, MJ;TAUXE, RV
为了确定与幽门螺杆菌感染相关的症状和危险因素，对341名流行病学家进行了队列研究。所有受试者都有一份血清库（收集于1969年至1987年之间）和一份最近的血清样本（收集于1988年）评估h。酶联免疫吸附法检测幽门免疫球蛋白G；受试者提供了有关胃炎和消化性溃疡疾病的胃肠道症状和危险因素的信息。从20世纪70年代初到现在，感染率有所下降。11名受试者（占总队列的3%）在血清样本间隔期间进行了血清转化，得出每人年的粗转化率为0.49%（95%置信区间为0.3-0.9）。1988年血清样本的非反应物描述了与反应物相似的症状。然而，在两种血清样本之间进行血清转化的受试者比持续未反应者[相对危险度（RR）， 4.1]或持续反应者（RR, 3.7）更有可能在间隔年出现上消化道症状。饮用含咖啡因的饮料（相对危险度4.6）和居住在美国东北部（相对危险度5.3）似乎会增加感染的风险。因为疼痛在h。幽门螺杆菌阳性和阴性患者，H。即使确认感染，也不能立即接受幽门螺杆菌为消化不良症状的原因。
To identify symptoms and risk factors associated withHelicobacter pyloriinfection, a cohort of 341 epidemiologists was studied. All subjects had one banked serum (collected between 1969 and 1987) and one recent serum sample (collected in 1988) evaluated forH. pyloriimmunoglobulin G by enzyme-linked immunosorbent assay; subjects provided information on gastrointestinal symptoms and risk factors for gastritis and peptic ulcer disease. Prevalence of infection decreased from the early 1970s to the present. Eleven subjects (3% of the total cohort) seroconverted during the interval between serum samples, giving a crude conversion rate of 0.49% per person-year (95% confidence interval, 0.3–0.9). Nonreactors on the 1988 serum sample described similar symptoms to reactors. However, subjects who seroconverted in the interval between the two serum samples were more likely than either persistent nonreactors [relative risk (RR), 4.1] or persistent reactors (RR, 3.7) to have experienced upper gastrointestinal symptoms in the interval years. Consumption of caffeinated beverages (RR, 4.6) and residence in the northeastern United States (RR, 5.3) seemed to increase risk for infection. Because pain was similarly common inH. pylori-positive and -negative patients,H. pyloricannot be summarily accepted as the cause of dyspeptic symptoms even when infection is confirmed.