Ethnic Differences in Experimental Pain Responses Following a Paired Verbal Suggestion With Saline Infusion: A Quasiexperimental Study.
Ethnic Differences in Experimental Pain Responses Following a Paired Verbal Suggestion With Saline Infusion: A Quasiexperimental Study.
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配对口头建议与盐水输注后实验性疼痛反应的种族差异：一项准实验研究。
DOI：
10.1093/abm/kaaa032
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Campbell,ClaudiaM
中科院分区：
文献类型：
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作者：
Letzen,JanelleE;Dildine,TroyC;Mun,ChungJung;Colloca,Luana;Bruehl,Stephen;Campbell,ClaudiaM
背景安慰剂和反安慰剂反应的种族差异是一个重要的，但研究不足，患者因素，可能有助于治疗的差异。目的本研究的目的是检查种族差异的疼痛轨迹后，口头建议配对与掩蔽，惰性物质（即，使用准实验设计，我们检查了21名非西班牙裔黑人（NHB）参与者和20名非西班牙裔白色（NHW）参与者在无方向性口头建议+盐水输注后辣椒素相关疼痛评级轨迹的差异。所有参与者都被告知，这种物质会“增加疼痛感，减少疼痛感，或者保持不变。”样条混合模型被用来量化的相互作用的种族和时间上ratings.ResultsThere是一个显着的种族×时间的相互作用效果（β =-0.28，P = .002）; NHB个人报告显着增加疼痛后，但不是之前，口头建议+盐水输注。敏感性分析显示，在教育水平，一般疼痛敏感性，或条件order.ConclusionsThe目前的结果显示，种族差异的疼痛反应轨迹后，口头建议+盐水输注的基础上的主要结果没有变化，并建议今后的研究严格检查可能的种族差异安慰剂/nocebo反应是必要的。
BackgroundEthnic differences in placebo and nocebo responses are an important, yet underresearched, patient factor that might contribute to treatment disparities.PurposeThe purpose of this study was to examine ethnic differences in pain trajectories following a verbal suggestion paired with a masked, inert substance (i.e., saline).MethodsUsing a quasiexperimental design, we examined differences between 21 non-Hispanic Black (NHB) participants and 20 non-Hispanic White (NHW) participants in capsaicin-related pain rating trajectories following a nondirectional verbal suggestion + saline infusion. All participants were told that the substance would “either increase pain sensation, decrease it, or leave it unchanged.” A spline mixed model was used to quantify the interaction of ethnicity and time on ratings.ResultsThere was a significant Ethnicity × Time interaction effect (β = −0.28,p = .002); NHB individuals reported significantly greater increases in pain following, but not before, the verbal suggestion + saline infusion. Sensitivity analyses showed no change in primary results based on differences in education level, general pain sensitivity, or condition order.ConclusionsThe present results showed ethnic differences in pain response trajectories following a verbal suggestion + saline infusion and suggest that future research rigorously examining possible ethnic differences in placebo/nocebo responses is warranted.