AN OVERVIEW OF ISSUES RELATED TO THE CORRECTION OF NON-DIFFERENTIAL EXPOSURE MEASUREMENT ERROR IN EPIDEMIOLOGIC STUDIES
AN OVERVIEW OF ISSUES RELATED TO THE CORRECTION OF NON-DIFFERENTIAL EXPOSURE MEASUREMENT ERROR IN EPIDEMIOLOGIC STUDIES
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DOI：
10.1002/sim.4780080903
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发表时间：
1989-09-01
影响因子：
2
通讯作者：
WILLETT, W
中科院分区：
文献类型：
--
作者：
WILLETT, W
在流行病学研究中，校正暴露测量误差影响的关联估计的程序在实践中很少采用。允许包含协变量、提供校正置信区间、与常用的分析方法兼容、并清楚地传达给潜在用户的方法将加强校正程序的应用。在使用这种方法之前，重要的是要明确定义概念上的“真实”暴露，确定测量误差的性质，并决定是否需要进行可重复性研究或有效性研究来量化误差。仔细使用校正程序有望提高我们对许多暴露与疾病之间定量关系的认识，因为我们很可能大大低估了许多暴露的影响，并高估了我们对无效结果的信心。
Procedures to correct estimates of association in epidemiologic studies for the effects of exposure measurement error have rarely been employed in practice. The application of correction procedures would be enhanced by methods that allow the inclusion of covariates, provide corrected confidence intervals, are compatible with commonly employed analytic methods, and that are clearly communicated to potential users. Before using such a procedure, it is important to clearly specify the conceptual ‘true’ exposure, determine the nature of the measurement error, and decide whether a reproducibility study or validity study is required to quantify the error. The careful use of correction procedures promises to improve our knowledge of the quantitative relationships between many exposures and disease since it is likely that we have substantially underestimated the effects of many exposures and overstated our confidence in null results.