The Prospective Sleeping Brain: Age-Related Differences in Episodic Future Thinking and Frontal Sleep Spindles
The Prospective Sleeping Brain: Age-Related Differences in Episodic Future Thinking and Frontal Sleep Spindles
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DOI：
10.1162/jocn_a_01716
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发表时间：
2021-07-01
影响因子：
3.2
通讯作者：
Scullin, Michael K.
中科院分区：
文献类型：
--
作者：
Fillmore, Paul;Gao, Chenlu;Scullin, Michael K.
睡眠纺锤波是脱机记忆巩固的生理标志。在年轻人中，睡眠纺锤波优先对被标记为与未来相关的编码信息做出反应。另一方面，老年人表现出对未来模拟和睡眠生理变化的能力降低。健康的年轻人(n=38)和老年人(n=28)完成了一个适应之夜，然后是两个实验室多导睡眠图之夜，在这两个夜晚中，他们用大脑模拟未来的事件或记住过去的事件，通过书面描述记录下来。我们使用时间取向的语言学分析来量化未来/过去思维的程度。在年轻人中，更多的未来思维与更大的纺锤密度有关，即使在控制性别、年龄和字数时也是如此(r(P)=.370，p=.028)。老年人的情况正好相反，未来思维能力越强，纺锤体密度越低(r(P)=-.431，p=.031)。这些模式对未来的思维是有选择性的(过去的思维没有观察到)。这些集体发现表明，未来的相关性标记和睡眠生理学之间的相互作用受损，这是衰老损害依赖睡眠的认知过程的一种机制。
Sleep spindles are a physiological marker of off-line memory consolidation. In young adults, sleep spindles are preferentially responsive to encoded information that is tagged as having future relevance. Older adults, on the other hand, show reduced capacity for future simulation and alterations in sleep physiology. Healthy young adults (n = 38) and older adults (n = 28) completed an adaptation night, followed by two in-laboratory polysomnography nights, in which they mentally simulated future events or remembered past events, recorded via written descriptions. We quantified the degree of future/past thinking using linguistic analysis of time orientation. In young adults, greater future thinking was linked to greater spindle density, even when controlling for gender, age, and word count (r(p) =.370, p =.028). The opposite was true for older adults, such that greater future thinking was associated with reduced spindle density (r(p) = -.431, p =.031). These patterns were selective to future thinking (not observed for past thinking). The collective findings implicate an impaired interaction between future relevance tagging and sleep physiology as a mechanism by which aging compromises sleep-dependent cognitive processing.