THE FORMATION OF POLYPEPTIDES BY REARRANGEMENT OF ALPHA-CARBOXY HYDROXAMIC ACIDS
THE FORMATION OF POLYPEPTIDES BY REARRANGEMENT OF ALPHA-CARBOXY HYDROXAMIC ACIDS
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DOI：
10.1021/ja01150a001
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发表时间：
1951-01-01
影响因子：
15
通讯作者：
BUESS, CM
中科院分区：
文献类型：
--
作者：
HURD, CD;BUESS, CM
合成了二羧基苯甲酰羟肟酸，以确定一个羧基对减量重排过程的影响。重排的产物包括多肽，无论在水、苯或乙醇中进行。这些产物的形成是由于羟基肟酸在中间转化为偶氮丁二酸酐，然后发生了Leuchs聚合。多肽被水解成相应的氨基酸。
Two-carboxy benzoylhydroxamic acids were synthesized in order to determine the effect of an-carboxy group on the course of the Lessen rearrangement. The products of the rearrangement included polypeptides, whether carried out in water, benzene or ethyl alcohol. The formation of these products is attributed to the intermediary transformation of the hydroxamic acids to azasuccinic anhydrides followedby the Leuchs polymerization. The polypeptides were hydrolyzed to the corresponding amino acids.