Adequacy of control of preoperative hypertension can affect landiolol-induced hemodynamic changes in elderly patients during emergence from anesthesia.
Adequacy of control of preoperative hypertension can affect landiolol-induced hemodynamic changes in elderly patients during emergence from anesthesia.
复制标题
术前高血压的充分控制可以影响兰地洛尔引起的老年患者麻醉苏醒期间的血流动力学变化。
DOI：
10.1007/s00540-010-1088-x
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发表时间：
2011
期刊：
影响因子：
2.8
通讯作者：
Saito S.
中科院分区：
文献类型：
--
作者：
Kadoi Y;Horiuchi T;Uchida S;Saito S.
我们研究了兰地洛尔对老年无控制高血压患者麻醉苏醒期间血流动力学的剂量相关影响。将33例血压正常、34例控制高血压和31例未控制高血压的老年患者分为3组：对照组(生理盐水输注)、0.125.2 5兰地洛尔组和0.2 5兰地洛尔组。兰地洛尔或生理盐水分别以0.125.0 5 mg/kg/m in(0.125.2 5 mg/kg/m in)或0.2 5 mg/kg/m in(0.2 5 m g/kg/m in)输注1min，然后分别降至0.0 4或0.0 8 m g/kg/m in，拔管前定期监测心率和血压。在血压正常的患者中，兰地洛尔0.125 mg/kg/min输注适合于拔管期间稳定收缩压和心率。控制性高血压患者拔管时需静脉滴注兰地洛尔0.25 mg/kg/min以稳定收缩压和心率。在未控制的高血压患者中，输注兰地洛尔0.25 mg/kg/min可以稳定心率，但不能稳定收缩压。结论：老年患者麻醉苏醒时，术前血压控制的充分性可能影响兰地洛尔输注诱导的血流动力学稳定性。
We examined the dose-related effects of landiolol on hemodynamics during emergence from anesthesia of elderly patients with uncontrolled hypertension. Thirty-three normotensive, 34 controlled hypertensive, and 31 uncontrolled hypertensive elderly patients were divided into three groups: control (saline infusion), 0.125 landiolol group, and 0.25 landiolol group. Landiolol or saline infusion was administered at 0.125 (0.125 landiolol group) or 0.25 (0.25 landiolol group) mg/kg/min for 1 min and thereafter decreased to 0.04 or 0.08 mg/kg/min, respectively, until extubation, under regular heart rate and blood pressure monitoring. In normotensive patients, the 0.125 mg/kg/min landiolol infusion was suitable for stabilization of systolic blood pressure and heart rate during tracheal extubation. Controlled hypertensive patients required a 0.25 mg/kg/min landiolol infusion for stabilization of systolic blood pressure and heart rate during tracheal extubation. In uncontrolled hypertensive patients the 0.25 mg/kg/min landiolol infusion could stabilize heart rate, but not systolic blood pressure. In conclusion, the adequacy of preoperative hypertensive control could affect landiolol infusion-induced hemodynamic stability during emergence of elderly patients from anesthesia.