Role of the Spacer of cationic gemini amphiphiles in the condensation of DNA
Role of the Spacer of cationic gemini amphiphiles in the condensation of DNA
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DOI：
10.1021/la051324
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发表时间：
2005-11-08
期刊：
影响因子：
3.9
通讯作者：
Sacco, MG
中科院分区：
文献类型：
--
作者：
Bombelli, C;Borocci, S;Sacco, MG
小牛胸腺DNA的凝聚成胆固醇样的PSI-相，观察到圆二色性在脂质体悬浮液配制特定的阳离子双子表面活性剂。双子间隔子的立体化学、特定官能团的存在以及头基之间的共价连接是DNA缩合中的基本问题。透射电子显微镜图像显示出多层形态，这与冷凝相对应。
The condensation of calf thymus DNA into the cholesteric-like Psi-phase was observed by circular dichroism in liposome suspensions formulated with specific cationic gemini surfactants. The stereochemistry of the gemini spacer, the presence of specific functional groups, and the covalent link between the headgroups are fundamental issues in the condensation of DNA. Transmission electron microscopy images showed a multilamellar morphology, which corresponds with condensation.