Differential effect of Serratia protease on platelet surface glycoproteins Ib and V
Differential effect of Serratia protease on platelet surface glycoproteins Ib and V
复制标题
沙雷氏菌蛋白酶对血小板表面糖蛋白 Ib 和 V 的差异作用
DOI：
10.1182/blood.v65.4.1033.bloodjournal6541033
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发表时间：
1985
期刊：
影响因子：
20.3
通讯作者：
T. Detwiler
中科院分区：
文献类型：
--
作者：
E. McGowan;T. Detwiler
The effect of a zinc metalloprotease from Serratia marcescens on platelet surface glycoproteins (GP) Ib and V was analyzed. Increasing protease treatments caused progressive loss of GP Ib with appearance of the major fragment, glycocalicin, in the supernatant solution. No GP V was detected in the supernatant solution, and protease-pretreated platelets had the same capacity as control platelets to release fragment 1 of GP V in response to thrombin. The Serratia protease- pretreated platelets did show the lag before thrombin-induced dense granule secretion, characteristic of platelets modified by pretreatment with other nonstimulating proteases. Treatment with Serratia protease gives the only demonstrated selective loss of GP Ib without apparent effect on GP V. It suggests that GP V (1) does not depend on GP Ib for its association with platelets and (2) is not the substrate for protease modification of platelet function.
通过蛋白水解酶暴露人血小板上的纤维蛋白原受体。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Niewiarowski,S;Budzynski,AZ;Morinelli,TA;Brudzynski,TM;Stewart,GJ
通讯作者：
Stewart,GJ
人血小板膜糖蛋白V的纯化和初步理化表征。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Berndt,MC;Phillips,DR
通讯作者：
Phillips,DR
用粘质沙雷氏菌金属蛋白酶水解人血小板膜糖蛋白：对凝血酶和血管性血友病因子反应的影响。
DOI：
10.1073/pnas.79.5.1433
发表时间：
1982
影响因子：
11.1
作者：
Cooper,HA;Bennett,WP;White2nd,GC;Wagner,RH
通讯作者：
Wagner,RH