Lower Bone Mineral Density in Patients with Parkinson's Disease: A Cross-Sectional Study from Chinese Mainland.
Lower Bone Mineral Density in Patients with Parkinson's Disease: A Cross-Sectional Study from Chinese Mainland.
复制标题
帕金森病患者骨矿物质密度较低：来自中国大陆的横断面研究。
DOI：
10.3389/fnagi.2015.00203
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发表时间：
2015
影响因子：
4.8
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Gao H;Wei X;Liao J;Wang R;Xu J;Liu X;Pan X;Li Z;Li Z;Xia Y;Wang Q
与健康受试者相比，两种性别的PD患者的BMD均显著较低。>80%的PD患者Ca-P产物低于35 mg 2/dl 2。BMD与PD严重程度显著相关。H&Y III/IV期BMD低于H&Y I/II期。尽管有多项证据表明帕金森病（PD）患者发生骨质疏松症和骨折的风险较高，但骨矿物质密度（BMD）与PD患者严重程度之间的相关性尚不清楚。我们对54名PD患者和59名年龄匹配的健康对照者进行了一项横断面研究。采用多种临床量表评估PD的严重程度，并测定血清钙、磷和同型半胱氨酸水平以确定BMD与PD严重程度的相关性。PD患者的BMD明显低于健康对照组。健康组女性脊柱、股骨颈（FN）和髋部的BMD评分低于男性。在PD组中，女性髋部BMD显著低于男性。在PD组中，每日左旋多巴剂量与脊柱和髋部的BMD呈负相关，而脊柱、颈部和髋部的BMD与PD的严重程度显著相关。此外，我们发现在腰椎（LS）、FN和髋关节中，基于T评分，LS的骨丢失在PD患者中最严重。我们的研究结果支持这一假设，即PD患者有更高的骨质疏松症的风险，低BMD的脊柱，FN和髋关节可能间接反映PD的严重程度。我们的研究结果提示我们在中国PD患者LS中更加关注骨质疏松。
Significantly lower BMD in PD compared to healthy subjects in both genders. Less than 35 mg2/dl2 of Ca–P product in >80% of PD patients. Significant correlations between BMD and severity of PD. Lower BMD at H&Y stage III/IV than that at H&Y stage I/II. Although several lines of evidence have suggested that patients with Parkinson’s disease (PD) have a higher risk of osteoporosis and fracture, the association between bone mineral density (BMD) and severity of PD patients is unknown. We performed a cross-sectional study of 54 patients with PD and 59 healthy age-matched controls. Multiple clinical scales were used to evaluate the severity of PD, and serum levels of calcium, phosphorus, and homocysteine were measured to determine BMD’s association with PD severity. BMD in PD patients was significantly lower than that in healthy controls. The BMD scores of the spine, femoral neck (FN), and hip were lower in females than in males in the healthy group. In the PD group, BMD in the hip was significantly lower in females compared to males. There was a negative correlation between daily l-DOPA dosage and BMD in the spine and hip in the PD group, while BMD in the spine, neck, and hip was significantly correlated with severity of PD. Besides, we found that among the lumbar spine (LS), FN, and hip, bone loss in the LS was the most severe in PD patients based on the T-scores. Our findings support the hypothesis that patients with PD have a higher risk of osteoporosis, and that low BMD in the spine, FN, and hip may indirectly reflect the severity of PD. Our findings have prompted us to pay more attention to osteoporosis in the LS in Chinese PD patients.