Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma
Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma
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肝细胞癌中SMP30的血清免疫反应性及其组织表达
DOI：
10.1016/j.clinbiochem.2010.10.008
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发表时间：
2011-03-01
影响因子：
2.8
通讯作者：
Luo, Guo-Rong
中科院分区：
文献类型：
--
作者：
Zhou, Su-Fang;Mo, Fa-Rong;Luo, Guo-Rong
Objectives: To detect serum antibody against SMP30 in HCC patients and to evaluate its potential associations with HCC patient's clinical parameter and expression levels in HCC tissues.Design and Methods: Serum antibody to SMP30 was tested by ELISA method; SMP30 mRNA and protein expression in HCC patients were analyzed using the methods of in situ nucleic acid hybridization and immunohistochemistry, respectively.Results: The highest relevance of SMP30 antibody was associated with HCC (32.4%). The positive rate of SMP30 antibody was not related to the age of patients, tumor size, metastasis and infections of HBV, but the positive rate for SMP30 antibody in the HCC sera with alpha-fetoprotein (AFP) negative was higher (43.6%) compared with that AFP positive (26.2%). Both SMP30 mRNA and protein expression levels were downregulated in HCC and upregulated in adjacent tissues.Conclusions: SMP30 may be useful for HCC serologic screening, especially for the patients with AFP negative. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
