Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?
Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?
复制标题
药物遗传学和药物在怀孕期间失败的其他原因：更高剂量或不同药物？
DOI：
10.1097/aog.0b013e3182698538
复制
发表时间：
2012
影响因子：
7.2
通讯作者：
DʼAlton,Mary
中科院分区：
文献类型：
--
作者：
Haas,DavidM;DʼAlton,Mary
Changes in maternal physiology during pregnancy can alter the absorption, distribution, and clearance of many drugs. When presented with a clinical situation in which it does not appear that a prescribed drug is working, clinicians must either change drugs or increase the dose of the current drug to achieve the desired clinical effect. A case highlighting antihypertensive medication in pregnancy and the effect of changed drug-metabolizing enzymes is presented. Understanding pregnancy's effect on drug-metabolizing enzymes, transporters, and receptors can help clinicians make individualized pharmacotherapeutic decisions for patients. Pharmacogenetics potentially can aid clinicians in treating pregnant women in the future as more data are generated and individualized therapeutic models are constructed.
