Amniotic fluid: the first feeding of mucosal immune factors.
Amniotic fluid: the first feeding of mucosal immune factors.
复制标题
羊水：粘膜免疫因子的第一喂养。
DOI：
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发表时间：
1991
影响因子：
--
通讯作者：
R. Goldblum
中科院分区：
文献类型：
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作者：
Mark G. Cleveland;M. Bakos;Susan M. Hilton;R. Goldblum
羊水(AMF)为胎儿提供保护环境。AMF中存在许多通常在包括牛奶在内的粘膜分泌物中发现的免疫因子。其中包括几种天然抗微生物物质，如溶菌酶、乳铁蛋白、转铁蛋白、过氧化物酶和干扰素-α1-5。尽管羊水蛋白浓度总体下降，但大多数这些因子在羊水中的浓度随着胎儿的成熟而增加。AMF中的特异性免疫因素包括母源免疫球蛋白和低水平的IgA和IgM6。根据同种异型标记A2M7，AMF中的IgA2已被证明是胎儿起源的。从妊娠早期(14-20周)和晚期(30-40周)的AMF样本中可以检测到针对大肠杆菌和脊髓灰质炎病毒的低水平IgA、IgM和分泌成分(SC)阳性抗体8。然而，在这些样本中检测到这些抗体的频率似乎并没有随着孕龄的增加而增加。
Amniotic fluid (AmF) provides a protective environment for the unborn fetus. A number of immunologic factors typically found in mucosal secretions, including milk, are present in AmF. These include several innate anti-microbial substances such as lysozyme, lactoferrin, transferrin, peroxidase, and interferon-α1–5. The concentration of most of these factors increases in the AmF as the fetus matures, despite an overall decline in amniotic fluid protein concentration2. Specific immunologic factors in the AmF include maternally derived IgG and low levels of IgA and IgM6. The IgA2 in AmF has been shown to be of fetal origin based on the allotypic marker A2m7. Low levels of IgA, IgM and secretory component (SC)-positive antibodies specific for Escherichia coli and poliovirus are detectable in AmF from early (14–20 wks) and late (30–40 wks) gestational samples8. However, the frequency of detecting these antibodies in these samples did not seem to increase with gestational age.
羊水中分泌成分的表征。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cleveland,MG;Bakos,MA;Pyron,DL;Rajaraman,S;Goldblum,RM
通讯作者：
Goldblum,RM