Aberrant resting-state cerebellar blood flow in major depression
Aberrant resting-state cerebellar blood flow in major depression
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DOI：
10.1016/j.jad.2017.09.028
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发表时间：
2018-01-15
影响因子：
6.6
通讯作者：
Wolf, Robert C.
中科院分区：
文献类型：
--
作者：
Depping, Malte S.;Wolf, Nadine D.;Wolf, Robert C.
背景资料：在重度抑郁症（MDD）患者中，经常报告皮质脑血流和灰质体积异常。相比之下，虽然小脑在MDD病理生理学中的作用最近引起了相当大的兴趣，但研究小脑完整性的功能和结构方面的研究很少。在本研究中，我们使用结构和功能磁共振成像（MRI）研究了临床急性MDD患者（n = 22）的小脑体积和静息时的局部小脑血流量（rCBF）健康对照组（n = 18）。我们获得了高分辨率的结构图像在3 T与灌注图像获得连续动脉自旋标记。结果：双侧小脑VIIa区和VIIIb区rCBF显著增加（p < 0.05，校正家族错误[FWE]）。患者和对照组之间小脑体积无显著差异（p < 0.05，FWE校正）。左小脑VIIa区灌注与抑郁症状显着相关，通过测量的汉密尔顿抑郁Rating Scale.Limitations：本研究的潜在局限性，包括适度的样本量，横断面设计，缺乏任务相关的成像和药物治疗的异质性。结论：数据表明贡献的“情感”小脑区域MDD的病理生理学和症状表达。虽然休息时小脑灌注受损MDD，小脑体积似乎受影响较小。
Background: Abnormal cortical cerebral blood flow and gray matter volume have been frequently reported in patients with major depressive disorder (MDD). In contrast, although the role of the cerebellum in MDD pathophysiology has attracted considerable interest more recently, studies investigating both functional and structural aspects of cerebellar integrity are scarce.Methods: In this study, we used structural and functional magnetic resonance imaging (MRI) to investigate cerebellar volume and regional cerebellar blood flow (rCBF) at rest in clinically acute MDD patients (n = 22) and healthy controls (n = 18). We acquired high-resolution structural images at 3 T together with perfusion images obtained with continuous arterial spin labeling. Cerebellar structure and function were investigated using cerebellum-optimized analysis techniques.Results: Markedly increased rCBF was found in bilateral cerebellar areas VIIa and VIIIb (p < 0.05 family-wise-error [FWE] corrected). Significant differences in cerebellar volume between patients and controls were not found (p < 0.05, FWE-corrected). Left cerebellar area VIIa perfusion was significantly associated with depressive symptoms, as measured by the Hamilton Depression Rating Scale.Limitations: Potential limitations of this study include the modest sample size, the cross-sectional design, the lack of task-related imaging and the heterogeneity of drug treatment.Conclusions: The data suggest contributions of "affective" cerebellar regions to MDD pathophysiology and symptom expression. While cerebellar perfusion at rest is compromised in MDD, cerebellar volume seems to be less affected.