Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation.
Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation.
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粪便 BAFF、钙卫蛋白和 FOBT 非侵入性生物标志物在区分 IBS 和 IBD 以及评估肠道炎症方面的比较
DOI：
10.1038/s41598-017-02835-5
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发表时间：
2017-06-01
影响因子：
4.6
通讯作者：
Hou X
中科院分区：
文献类型：
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作者：
Fu Y;Wang L;Xie C;Zou K;Tu L;Yan W;Hou X
粪便钙卫蛋白和粪便潜血试验（FOBT）被广泛用于炎症性肠病（IBD）肠道炎症的诊断和评估。最近，我们发现了一个很好的新的生物标志物B细胞活化因子（BAFF）的IBD。在本研究中，我们比较了粪便BAFF、钙卫蛋白和FOBT的功效，以找到“最佳非侵入性标记物”。结果显示，对于鉴别IBD和IBS，BAFF ≥227.3 pg/ml产生84%的灵敏度、100%的特异性、100%的阳性预测值（PPV）和64%的阴性预测值（NPV），而钙卫蛋白≥50 µg/g产生76%的灵敏度、93%的特异性、97%的PPV和53%的NPV。FOBT的敏感性为65%，特异性为93%，PPV为97%，NPV为43%。结合BAFF和钙卫蛋白测试产生94%的灵敏度，93%的特异性，98%的PPV，81%的NPV。与钙卫蛋白相比，粪便BAFF水平不仅在UC中（相关系数[r] = 0.69，p < 0.0001 vs. r = 0.58，p < 0.0001），而且在CD中（r = 0.58，p < 0.0001 vs. r = 0.52，p = 0.0003）与内镜炎症评分显示出更强的相关性。我们的研究结果表明，粪便BAFF是一个有前途的非侵入性生物标志物在IBD鉴别诊断和监测肠道炎症。
Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently we identified an excellent new biomarker B cell-activating factor (BAFF) for IBD. Here in this study we compared the efficacy of faecal BAFF, calprotectin and FOBT to find the “best non-invasive marker”. Results showed that for discriminating IBD from IBS, BAFF ≥227.3 pg/ml yield 84% sensitivity, 100% specificity, 100% positive predictive value (PPV) and 64% negative predictive value (NPV) while calprotectin ≥50 µg/g yield 76% sensitivity, 93% specificity, 97% PPV and 53% NPV. FOBT yield 65% sensitivity, 93% specificity, 97% PPV and 43% NPV. Combining BAFF with calprotectin tests yield 94% sensitivity, 93% specificity, 98% PPV, 81% NPV. Faecal BAFF level showed the stronger correlation with endoscopic inflammatory score as compared to calprotectin not only in UC (correlation coefficient [r] = 0.69, p < 0.0001 vs. r = 0.58, p < 0.0001), but also in CD (r = 0.58, p < 0.0001 vs. r = 0.52, p = 0.0003). Our results indicating that faecal BAFF is a promising non-invasive biomarker in IBD differential diagnosis and monitoring of intestinal inflammation.