Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level
Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level
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DOI：
10.1038/nm.2203
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发表时间：
2010-09-01
期刊：
影响因子：
82.9
通讯作者：
Schuitemaker, Hanneke
中科院分区：
文献类型：
--
作者：
Bunnik, Evelien M.;Euler, Zelda;Schuitemaker, Hanneke
通过比较流行初期感染者和最近感染者的HIV-1变异体，我们观察到随着时间的推移，病毒对抗体中和的抵抗力增强，同时可变环的长度和HIV-1包膜gp 120亚基上潜在的N-连接糖基化位点的数量增加。当代血清转换者中HIV-1的中和抗性增强与中和抗体应答的激发较差相一致，这可能对疫苗设计产生影响。
By comparing HIV-1 variants from people who became infected at the beginning of the epidemic and from people who have recently contracted the virus, we observed an enhanced resistance of the virus to antibody neutralization over time, accompanied by an increase in the length of the variable loops and in the number of potential N-linked glycosylation sites on the HIV-1 envelope gp120 subunit. The enhanced neutralization resistance of HIV-1 in contemporary seroconverters coincided with the poorer elicitation of neutralizing antibody responses, which may have implications for vaccine design.