Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors
Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors
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DOI：
10.1016/s0925-4005(01)01056-5
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发表时间：
2002-03-15
影响因子：
8.4
通讯作者：
Meixner, H
中科院分区：
文献类型：
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作者：
Fleischer, M;Simon, E;Meixner, H
通过应用不同的传感器原理，研究了人类呼吸中挥发性化合物的分析。呼吸中低ppb水平（2-100 ppb）的氮氧化物（哮喘标志物）的检测可以通过功函数测量来进行。通过使用铜酞菁染料作为气敏层，计算的检测限为1.3ppb。对水和氧浓度变化的低交叉灵敏度对于在呼吸分析中的使用是非常有利的。用石英微量天平（QMB）测量丙酮浓度，糖尿病的标志，可以在乙醇和水蒸气的存在下确定。两种传感器原理的比较显示没有相关性，因此，组合可以提高交叉灵敏度和传感器选择性。(C)2002 Elsevier Science B. V.保留所有权利。
The analysis of volatile compounds in the breath of humans was investigated by the application of different sensor principles. The detection of nitrogen oxide, an asthma marker, in breath at the low ppb-level (2-100 ppb) can be carried out by work function measurements. By the use of Cu-phthalocyanine dye as gas sensitive layer a calculated detection limit of 1.3 ppb is attainable. The low cross sensitivities to water and changes in the oxygen concentration are of great advantage for the use in breath analysis. With quartz microbalance (QMB) measurements acetone concentrations, a marker for diabetes, can be determined in the presence of ethanol and water vapor. The comparison of both sensor principles showed no correlation, hence, the combination can improve cross sensitivity and sensor selectivity. (C) 2002 Elsevier Science B.V. All rights reserved.