Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers.
Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers.
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DOI：
10.1186/s12890-022-01960-w
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发表时间：
2022-04-27
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Exposure to inhalational hazards during post-9/11 deployment to Southwest Asia and Afghanistan puts military personnel at risk for respiratory symptoms and disease. Pulmonary function and qualitative chest high resolution computed tomography (HRCT) are often normal in “deployers” with persistent respiratory symptoms. We explored the utility of quantitative HRCT imaging markers of large and small airways abnormalities, including airway wall thickness, emphysema, and air trapping, in symptomatic deployers with clinically-confirmed lung disease compared to controls. Chest HRCT images from 45 healthy controls and 82 symptomatic deployers with asthma, distal lung disease or both were analyzed using Thirona Lung quantification software to calculate airway wall thickness (by Pi10), emphysema (by percentage of lung volume with attenuation < -950 Hounsfield units [LAA%-950]), and three parameters of air trapping (expiratory/inspiratory total lung volume and mean lung density ratios, and LAA%-856). SAS v.9.4 was used to compare demographic and clinical characteristics between deployers and controls using Chi-Square, Fisher Exact or t-tests. Linear regression was used to assess relationships between pulmonary function and quantitative imaging findings. Gender and smoking status were not statistically significantly different between groups, but deployers were significantly younger than controls (42 vs 58 years, p < 0.0001), had higher body mass index (31 vs 28 kg/m2, p = 0.01), and had fewer total smoking pack-years (8 vs. 26, p = 0.007). Spirometric measures were not statistically significantly different between groups. Pi10 and LAA%-950 were significantly elevated in deployers compared to controls in unadjusted analyses, with the emphysema measure remaining significantly higher in deployers after adjustment for age, sex, smoking, BMI, and expiratory total lung volume. Air trapping parameters were more common in control images, likely due to differences in age and smoking between groups. Among deployers, LAA%-950 and Pi10 were significantly correlated with spirometric markers of obstruction based on ratio of forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) and/or percent predicted FEV1. Quantitative chest HRCT imaging analysis identifies emphysema in deployers with asthma and distal lung disease, and may be useful in detecting and monitoring deployment-related lung disease in a population where spirometry is typically normal.
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影响因子：
10
作者：
Martinez CH;Chen YH;Westgate PM;Liu LX;Murray S;Curtis JL;Make BJ;Kazerooni EA;Lynch DA;Marchetti N;Washko GR;Martinez FJ;Han MK;COPDGene Investigators
通讯作者：
COPDGene Investigators
影响因子：
4.3
作者：
Charbonnier, Jean-Paul;Pompe, Esther;Lynch, David A.
通讯作者：
Lynch, David A.
影响因子：
5.8
作者：
Kim, Victor;Desai, Parag;Criner, Gerard J.
通讯作者：
Criner, Gerard J.
影响因子：
3.7
作者：
Mohamed Hoesein FA;de Jong PA;Lammers JW;Mali WP;Schmidt M;de Koning HJ;van der Aalst C;Oudkerk M;Vliegenthart R;van Ginneken B;van Rikxoort EM;Zanen P
通讯作者：
Zanen P
DOI：
10.1164/rccm.201807-1351so
发表时间：
2019-02-01
影响因子：
24.7
作者：
Bhatt, Surya P.;Washko, George R.;Lynch, David A.
通讯作者：
Lynch, David A.