Effects of treadmill running in a rat model of chronic kidney disease.
Effects of treadmill running in a rat model of chronic kidney disease.
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DOI：
10.1016/j.bbrep.2018.09.001
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发表时间：
2018-12
影响因子：
2.7
通讯作者：
Avin KG
中科院分区：
文献类型：
--
作者：
Organ JM;Allen MR;Myers-White A;Elkhatib W;O'Neill KD;Chen NX;Moe SM;Avin KG
慢性肾脏疾病（CKD）进展导致肌肉骨骼功能障碍，与住院的可能性较高相关，并可预测住院和死亡率。尽管如此，仍然缺乏有效的干预措施来治疗肌肉骨骼功能障碍。我们研究了跑步机跑步作为一种干预措施，以改善慢性肾脏病大鼠模型的肌肉骨骼健康。CKD大鼠进行10周的跑台运动或不进行跑台运动（每组n = 8）。动物跑60分钟，每周5次，以8 m/min的速度开始，以18 m/min的速度结束（每周增加1 m/min）。跑步机训练对肌肉力量（评估为最大刺激扭矩），半放松时间（从峰值扭矩到50%的时间）或肌肉横截面积没有影响。总体而言，没有与CKD进展相关的生化改善。骨骼肌catabolism高于非运动的动物没有肌肉合成标记物或再生转录因子的伴随变化。这些结果表明，通过跑步机跑步实现的有氧运动在CKD动物中没有保护作用，实际上产生了潜在的有害影响（增加catabolism）。鉴于CKD患者的高患病率和严重的肌肉骨骼运动障碍，显然需要了解如何有效地规定运动，以使肌肉骨骼系统受益。患有进行性慢性肾病的动物在10周的跑步机跑步中没有骨骼肌受益。在进行10周跑步机跑步的动物中，没有与CKD进展相关的生化改善。在跑步机运动的动物中，骨骼肌的catenin较高，而没有伴随的合成增加。
Chronic kidney disease (CKD) progression results in musculoskeletal dysfunction that is associated with a higher likelihood of hospitalization and is predictive of hospitalizations and mortality. Despite this, there is a lack of effective interventions to treat the musculoskeletal dysfunction. We studied treadmill running as an intervention to improve musculoskeletal health in a translational rat model that has slowly progressive CKD. CKD rats were subjected to treadmill exercise or no treadmill exercise for 10 weeks (n = 8 each group). Animals ran for 60 min, 5 times per week starting at a speed of 8 m/min and ending at 18 m/min (1 m/min increase/week). Treadmill training had no effect on muscle strength (assessed as maximally stimulated torque), half-relaxation time (time from peak torque to 50%) or muscle cross-sectional area. Overall, there were no biochemical improvements related to CKD progression. Skeletal muscle catabolism was higher than non-exercised animals without a concomitant change in muscle synthesis markers or regeneration transcription factors. These results suggest that aerobic exercise, achieved via treadmill running was not protective in CKD animals and actually produced potentially harmful effects (increased catabolism). Given the high prevalence and dramatic musculoskeletal mobility impairment in patients with CKD, there is a clear need to understand how to effectively prescribe exercise in order to benefit the musculoskeletal system. Animals with progressive chronic kidney disease had no skeletal muscle benefit from 10 weeks of treadmill running. There were no biochemical improvements related to CKD progression in animals that underwent 10 weeks of treadmill running. Skeletal muscle catabolism was higher in treadmill exercised animals without a concomitant increase in synthesis.
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影响因子：
13.2
作者：
Plantinga, Laura C.;Johansen, Kirsten;Powe, Neil R.
通讯作者：
Powe, Neil R.
影响因子：
6.1
作者：
Organ, Jason M.;Srisuwananukorn, Andrew;Allen, Matthew R.
通讯作者：
Allen, Matthew R.
在慢性肾脏疾病中，骨骼肌再生和氧化应激发生了改变。
影响因子：
3.7
作者：
Avin KG;Chen NX;Organ JM;Zarse C;O'Neill K;Conway RG;Konrad RJ;Bacallao RL;Allen MR;Moe SM
通讯作者：
Moe SM
影响因子：
--
作者：
Bao, Yeran;Dalrymple, Lorien;Johansen, Kirsten L.
通讯作者：
Johansen, Kirsten L.
影响因子：
13.2
作者：
DeOreo, PB
通讯作者：
DeOreo, PB