A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
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DOI：
10.1126/science.1126088
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发表时间：
2006-04-21
期刊：
影响因子：
56.9
通讯作者：
Jones, JDG
中科院分区：
文献类型：
--
作者：
Navarro, L;Dunoyer, P;Jones, JDG
植物和动物在感知病原体相关分子模式（PAMP）如细菌鞭毛蛋白后激活防御。在拟南芥中，鞭毛蛋白的感知增加了对细菌假单胞菌的抗性，尽管所涉及的分子机制仍然难以捉摸。在这里，我们表明，鞭毛蛋白衍生的肽诱导的植物microRNA（miRNA），负调节信使RNA的F盒生长素受体TIR1，AFB2和AFB3。生长素信号的抑制限制了P.lingae的生长，暗示了生长素在疾病易感性和miRNA介导的生长素信号抑制抗性中的作用。
Plants and animals activate defenses after perceiving pathogen-associated molecular patterns (PAMPs) such as bacterial flagellin. In Arabidopsis, perception of flagellin increases resistance to the bacterium Pseudomonas syringae, although the molecular mechanisms involved remain elusive. Here, we show that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3. Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.