Prostate cancer risk assessment model: a scoring model based on the Swedish Family-Cancer Database
Prostate cancer risk assessment model: a scoring model based on the Swedish Family-Cancer Database
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DOI：
10.1136/jmedgenet-2011-100290
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发表时间：
2012-05-01
影响因子：
4
通讯作者：
Fallah, Mahdi
中科院分区：
文献类型：
--
作者：
Roudgari, Hassan;Hemminki, Kari;Fallah, Mahdi
背景许多前列腺癌（PC）风险评估模型已经开发出来，方法将1998年瑞典家族癌症数据库（FCD2010）中976859名年龄≥ 30岁的独立指标男性及其家族成员随机分为发育期（60%）、发育期（60%）和发育期（60%）。和验证（40%）数据集（随访10年）。采用考克斯模型的HR外推风险评分
Background Many prostate cancer (PC) risk assessment models have been developed, however almost none include familial history.Aim To produce a risk assessment model for PC based on familial background of related cancers.Method 976 859 independent index men aged >= 30 in year 1998 and their family members in the Swedish Family-Cancer Database (FCD2010) were randomly divided into development (60%) and validation (40%) datasets (follow-up 10 years). The HR from Cox model was used to extrapolate risk scores.Results Specified scores were: for PC in situ at age