Synchronization of a circadian rhythm in pinealectomized European starlings by daily injections of melatonin
Synchronization of a circadian rhythm in pinealectomized European starlings by daily injections of melatonin
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通过每天注射褪黑激素来同步松果体切除的欧洲椋鸟的昼夜节律
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
I. Benzinger
中科院分区：
文献类型：
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作者：
E. Gwinner;I. Benzinger
我们已经验证了一种假设，即鸟类松果体激素褪黑素是一种化学介质，它以昼夜节律的时间模式在松果体中产生和分泌，驱动公开的昼夜节律功能。摘除松果体的欧洲八哥在持续昏暗的光线下，每天在同一时间肌肉注射褪黑素，持续数周。对照鸟只接受了芝麻油注射。在22只鸡中，有21只用褪黑激素处理后，运动活动与24小时注射节律同步。相比之下，10只对照鸟中只有1只的活动与每日注射的对照鸟同步。这些结果与褪黑素浓度的内源性昼夜节律提供内部同步剂的假设一致，直接作用于其他昼夜节律振荡器。或者，外源性节律似乎可能通过改变睡眠-觉醒周期间接地发挥作用。
SummaryWe have tested the hypothesis that the avian pineal hormone, melatonin, which is produced in and secreted from the pineal body in a circadian temporal pattern is a chemical mediator which drives overt circadian functions. Pinealectomized European starlings (Sturnus vulgaris) kept in continuous dim light, received intramuscular injections of melatonin at the same time each day for several weeks. Control birds received only sesame oil injections. In 21 out of 22 birds, melatonin treatment resulted in the synchronization of locomotor activity with the 24 h injection rhythm. In contrast, activity of only one out of 10 control birds became synchronized with the daily control injections. These results are consistent with the hypothesis that the endogenous circadian rhythm of melatonin concentration provides an internal synchronizing agent, acting directly on other circadian oscillators. Alternatively, it seems possible that the exogenous rhythm exerts its effect indirectly by modifying the sleep-wake cycle.