Experience of long-term synbiotic therapy in seven short bowel patients with refractory enterocolitis
Experience of long-term synbiotic therapy in seven short bowel patients with refractory enterocolitis
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DOI：
10.1016/j.jpedsurg.2004.07.013
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发表时间：
2004-11-01
影响因子：
2.4
通讯作者：
Tanaka, R
中科院分区：
文献类型：
--
作者：
Kanamori, Y;Sugiyama, M;Tanaka, R
背景/目的：益生菌和益生元疗法是治疗各种肠道疾病的有效新策略，包括炎症性肠病以及病毒和细菌感染。合生元被定义为益生菌和益生元的联合使用，预计其对肠道疾病的作用比单独使用益生菌或益生元更强，但尚无其临床应用的报道。作者设计了一种由短双歧杆菌、干酪乳杆菌和低聚半乳糖组成的合生元疗法方案，并初步确定了其在人体中的临床效果。
方法：该合生元疗法方案应用于7例患有难治性小肠结肠炎的短肠营养不良患者超过1年。（该方案使肠道）菌群（诱导厌氧菌占优势并抑制病原菌的定植）以及粪便中短链脂肪酸增加（从每克湿粪便27.8微摩尔增加到65.09微摩尔）。除1例外，所有患者体重增加加快，5例患者血清快速转换蛋白增加。
结论：这种合生元疗法方案可能是肠道菌群的有效调节剂，是治疗难治性小肠结肠炎短肠患者的一种有前景的策略。（C）2004爱思唯尔公司。保留所有权利。
Background/Purpose: Probiotic and prebiotic therapies are potent new strategies to treat various intestinal diseases, including inflammatory bowel disease and viral and bacterial infections. Synbiotics is defined as the combined use of probiotics and prebiotics and is expected to have a stronger effect on intestinal diseases than probiotics or prebiotics alone, but there has been no report of its clinical application. The authors designed a protocol for synbiotic therapy composed of Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides and preliminarily ascertained its clinical effects in humans.Methods: This protocol of synbiotic therapy was applied for more than 1 year to 7 malnourished patients with short bowels who suffered from refractory enterocolitis.bacterial flora (inducing the domination by anaerobic bacteria and suppressing the residence of pathogenic bacteria) and increased short chain fatty acids in the feces (from 27.8 to 65.09 mumol/g wet feces). All patients but 1 accelerated their body weight gain, and 5 patients showed increased serum rapid turnover proteins.Conclusions: This protocol for synbiotic therapy might be a potent modulator of intestinal flora and a promising strategy to treat short bowel patients with refractory enterocolitis. (C) 2004 Elsevier Inc. All rights reserved.