A MORPHOLOGICAL-STUDY OF EXPERIMENTAL MONONEUROPATHY IN THE RAT - EARLY ISCHEMIC CHANGES
A MORPHOLOGICAL-STUDY OF EXPERIMENTAL MONONEUROPATHY IN THE RAT - EARLY ISCHEMIC CHANGES
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DOI：
10.1016/0022-510x(94)90066-3
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发表时间：
1994-12-20
影响因子：
4.4
通讯作者：
RO, LS
中科院分区：
文献类型：
--
作者：
JACOBS, JM;RO, LS
本文描述了早期形态学的变化后，放置四个松散的结扎周围的大鼠坐骨神经，一种方法，用于产生改变疼痛相关的行为。结扎是为了不压迫神经，但有些神经外膜血管受到压迫。这种轻度病变在8.5小时内引起行为改变和神经纤维异常。神经纤维变化的分布是斑片状的，最初是由于停滞性缺血，伴有许旺细胞坏死和轴突停滞的证据。到48小时，神经内膜水肿增加，导致压迫性病变，并最终导致严重的神经纤维变性。
This paper describes early morphological changes following the placement of four loose ligatures round the rat sciatic nerve, a method used to produce altered pain-related behaviour. The ligatures were tied so as not to constrict the nerve, but there was compression of some epineurial blood vessels. This mild lesion caused behavioural changes and nerve fiber abnormalities within 8.5 h. The distribution of nerve fiber changes was patchy, and initially due to stagnant ischemia, with necrosis of Schwann cells and evidence of axonal stasis. By 48 h, endoneurial oedema increased leading to a compressive lesion and eventually to severe nerve fiber degeneration.