Lessons learned from molecular defects in nuclear factor κB dependent signaling
Lessons learned from molecular defects in nuclear factor κB dependent signaling
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DOI：
10.1016/j.micinf.2005.10.030
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发表时间：
2006-04-01
影响因子：
5.8
通讯作者：
Geha, Raif
中科院分区：
文献类型：
--
作者：
McDonald, Douglas R.;Janssen, Riny;Geha, Raif
核因子（NF）κ B是一种广泛表达的转录因子，在正常发育和炎症中起关键作用。通过小鼠敲除模型补充的导致NF κ B B活化的信号通路中天然存在的缺陷的表征已经证明NF κ B B在正常宿主防御中的重要作用。(c)2006年爱思唯尔SAS。All rights reserved.
Nuclear factor (NF) kappa B is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NF kappa B, complemented by mouse knockout models, has demonstrated the vital role of NF kappa B in normal host defense. (c) 2006 Elsevier SAS. All rights reserved.