Neuroimaging in Animal Seizure Models with (18)FDG-PET.
Neuroimaging in Animal Seizure Models with (18)FDG-PET.
复制标题
使用 (18)FDG-PET 对动物癫痫模型进行神经成像。
DOI：
10.1155/2011/369295
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tsirka,StellaE
中科院分区：
文献类型：
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作者：
Mirrione,MartineM;Tsirka,StellaE
小动物神经成像已越来越多地提供给研究人员，扩大了用这些方法研究的问题的广度。将这些非侵入性技术应用于癫痫发生的潜在问题也不例外。 小动物神经影像学的一个主要优势是它的翻译吸引力。 研究可以很好地控制和操纵，在疾病发作或疾病治疗之前，期间和之后检查动物的活脑。这些结果也可以与从人类患者身上收集的数据进行比较。 在过去的十年中，我们和其他人已经探索了癫痫动物模型的代谢模式，以深入了解疾病发展的基础电路。 在本文中，我们提供了如何使用2-脱氧-2 [18 F]氟代-D-葡萄糖（18 FDG）和正电子发射断层扫描（PET）进行代谢成像的技术细节，并解释了这些研究的优势和局限性。 我们还将强调通过小动物成像了解癫痫发生的最新进展。
Small animal neuroimaging has become increasingly available to researchers, expanding the breadth of questions studied with these methods. Applying these noninvasive techniques to the open questions underlying epileptogenesis is no exception. A major advantage of small animal neuroimaging is its translational appeal. Studies can be well controlled and manipulated, examining the living brain in the animal before, during, and after the disease onset or disease treatment. The results can also be compared to data collected on human patients. Over the past decade, we and others have explored metabolic patterns in animal models of epilepsy to gain insight into the circuitry underlying development of the disease. In this paper, we provide technical details on how metabolic imaging that uses 2‐deoxy‐2[18F]fluoro‐D‐glucose (18FDG) and positron emission tomography (PET) is performed and explain the strengths and limitations of these studies. We will also highlight recent advances toward understanding epileptogenesis through small animal imaging.