Biological characterization of chicken insulin activity in rats and domestic fowl.
Biological characterization of chicken insulin activity in rats and domestic fowl.
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大鼠和家禽中鸡胰岛素活性的生物学特征。
DOI：
10.1210/endo-83-6-1331
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发表时间：
1968
期刊：
影响因子：
4.8
通讯作者：
H. Pollock
中科院分区：
文献类型：
--
作者：
R. Hazelwood;J. Kimmel;H. Pollock
从鸡胰腺制备的结晶胰岛素在体外大鼠横隔膜生物试验中的活性与结晶牛肉、绵羊和猪肉胰岛素相同，但与等量(按重量计)的哺乳动物激素相比，在促进完整鸡的低血糖方面要有效得多。不同种类的胰岛素和干扰血浆物质之间的一级结构差异是关于经常报道的禽类对非禽类胰岛素的“抵抗力”的讨论。(内分泌学83：1331,1968)
Crystalline insulin prepared from chicken pancreas was as active as crystalline beef, sheep and pork insulins in an in vitro rat diaphragm bioassay, but was considerably more effective in promoting hypoglycemia in intact chickens when compared with equivalent amounts (by weight) of mammalian hormone. Primary structure differences among various species of insulin and interfering plasma substances are discussed with respect to the oft-reported avian “resistance” to non-avian insulin. (Endocrinology 83: 1331, 1968)