Starts of bacterial genes: estimating the reliability of computer predictions
Starts of bacterial genes: estimating the reliability of computer predictions
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DOI：
10.1016/s0378-1119(99)00200-0
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发表时间：
1999-07-08
期刊：
影响因子：
3.5
通讯作者：
Gelfand, M
中科院分区：
文献类型：
--
作者：
Frishman, D;Mironov, A;Gelfand, M
基因起始位点的精确定位是计算机辅助原核生物基因组功能分析中的一个重要问题。我们描述了一种算法，用于寻找核糖体结合位点，而无需学习样本。该算法对于分析具有很少或没有实验定位基因的基因组特别有用。给定基因组的核糖体结合位点（RBS）特性与潜在基因起始预测准确性之间存在明显的相关性。这种相关性是相当大的预测能力，并可能是有用的，估计未来的基因组分析工作的预期成功。我们还表明，RES属性依赖于基因组的系统发育位置。(C)1999 Elsevier Science B.V.保留所有权利。
Exact mapping of gene starts is an important problem in the computer-assisted functional analysis of newly sequenced prokaryotic genomes. We describe an algorithm for finding ribosomal binding sites without a learning sample. This algorithm is particularly useful for analysis of genomes with little or no experimentally mapped genes. There is a clear correlation between the ribosomal binding site (RBS) properties of a given genome and the potential gene start prediction accuracy. This correlation is of considerable predictive power and may be useful for estimating the expected success of future genome analysis efforts. We also demonstrate that the RES properties depend on the phylogenetic position of a genome. (C) 1999 Elsevier Science B.V. All rights reserved.