Total synthesis of the topopyrones: a new class of topoisomerase I poisons.
Total synthesis of the topopyrones: a new class of topoisomerase I poisons.
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拓扑吡喃酮的全合成：一类新的拓扑异构酶 I 毒物。
DOI：
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发表时间：
2008
影响因子：
3.6
通讯作者：
S. Hecht
中科院分区：
文献类型：
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作者：
Mark A. Elban;S. Hecht
拓扑吡喃酮代表一类新的高细胞毒性拓扑异构酶I毒物。已经完成了该类所有四种天然存在的成员的有效全合成。合成的关键要素包括使用两种新的二烯的Diels-Alder反应和钛介导的邻位定向Friedel-Crafts酰化反应。此外，两个氯化类似物可从先进的中间体的合成进行了描述。
The topopyrones represent a new class of highly cytotoxic topoisomerase I poisons. Efficient total syntheses of all four naturally occurring members of this class have been accomplished. Key elements of the syntheses include Diels-Alder reactions employing two novel dienes and a titanium-mediated ortho-directed Friedel-Crafts acylation. Additionally, the syntheses of two chlorinated analogues accessible from an advanced intermediate are described.