Relationship of leukocyte elastase concentration to severity of emphysema in homozygous alpha1-antitrypsin-deficient persons.
Relationship of leukocyte elastase concentration to severity of emphysema in homozygous alpha1-antitrypsin-deficient persons.
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纯合 α1-抗胰蛋白酶缺乏者白细胞弹性蛋白酶浓度与肺气肿严重程度的关系。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
I. Crawford
中科院分区：
文献类型：
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作者：
Y. Kidokoro;T. C. Kravis;K. Moser;J. C. Taylor;I. Crawford
在 9 名 40 至 53 岁的α1-抗胰蛋白酶缺乏（PiZZ）人群中，探讨了多形核白细胞颗粒弹性蛋白酶浓度与吸烟之间的关系以及详细肺功能测试的异常程度。无论使用何种统计分析方法，弹性蛋白酶浓度与肺功能测试中观察到的异常程度的相关性比吸烟史更频繁、更显着。数据表明，PiZZ 人群肺功能障碍的严重程度可能由年龄和吸烟以外的变量决定，包括白细胞溶酶体中弹性蛋白酶的浓度。
In 9 alpha1-antitrypsin-deficient (PiZZ) persons 40 to 53 years of age, the relationships between the concentration of elastolytic protease of polymorphonuclear leukocyte granules and cigarette smoking, and the degree of abnormality in detailed pulmonary function tests were explored. Regardless of the statistical analytic approach used, elastase concentration was related more frequently and significantly than smoking history to the degree of abnormality observed in tests of pulmonary function. The data suggest that the severity of pulmonary dysfunction in PiZZ persons may be determined by variables other than age and cigarette smoking, including the concentration of elastolytic protease in leukocyte lysosomes.