Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading.
Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading.
复制标题
肌腱干/祖细胞及其与细胞外基质和机械负荷的相互作用。
DOI：
10.1155/2019/3674647
复制
发表时间：
2019
影响因子：
4.3
通讯作者：
Wang James H-C
中科院分区：
文献类型：
--
作者：
Zhang Chuanxin;Zhu Jun;Zhou Yiqin;Thampatty Bhavani P;Wang James H-C
肌腱是一种独特的结缔组织，其生物学特性在很大程度上取决于其肌腱特异性干细胞、干细胞周围的细胞外基质(ECM)、施加在肌腱上的机械载荷条件以及它们之间的复杂相互作用。本文就肌腱干/祖细胞的鉴定、鉴定及其与细胞外基质和机械负荷的相互作用等方面的最新进展作一综述。此外，还讨论了这些相互作用对肌腱内稳态的维持和肌腱病理状态的启动的影响。此外，还概述了TSPC机制生物学在体内外进一步研究中面临的挑战。最后，对未来的研究工作提出了建议，包括使用特定的基因敲除模型和单细胞转录图谱，以使人们能够广泛和深入地了解肌腱的生理和病理生理学。
Tendons are unique connective tissues in the sense that their biological properties are largely determined by their tendon‐specific stem cells, extracellular matrix (ECM) surrounding the stem cells, mechanical loading conditions placed on the tendon, and the complex interactions among them. This review is aimed at providing an overview of recent advances in the identification and characterization of tendon stem/progenitor cells (TSPCs) and their interactions with ECM and mechanical loading. In addition, the effects of such interactions on the maintenance of tendon homeostasis and the initiation of tendon pathological conditions are discussed. Moreover, the challenges in further investigations of TSPC mechanobiologyin vitroandin vivoare outlined. Finally, future research efforts are suggested, which include using specific gene knockout models and single‐cell transcription profiling to enable a broad and deep understanding of the physiology and pathophysiology of tendons.