Molecular mechanisms of nonmuscle myosin-II regulation
Molecular mechanisms of nonmuscle myosin-II regulation
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DOI：
10.1016/s0955-0674(99)80004-0
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发表时间：
1999-02-01
影响因子：
7.5
通讯作者：
Bresnick, AR
中科院分区：
文献类型：
--
作者：
Bresnick, AR
肌球蛋白II是形成双极肌丝的常规双头肌球蛋白，直接参与调节非肌肉细胞的胞质分裂、细胞运动和细胞形态。为了了解非肌肉肌球蛋白II调节这些过程的机制，研究人员现在正在研究脊椎动物非肌肉细胞中这种分子的调节。非肌肌球蛋白-II，其活动和调节不同于平滑肌肌球蛋白-II的多种亚型的鉴定表明，除了调节轻链磷酸化，其他调节机制控制脊椎动物非肌肌球蛋白-II的活性。
Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.