The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments.
The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments.
复制标题
革兰氏阴性细菌的表面脂蛋白：恶劣环境中的保护剂和觅食者。
DOI：
10.1074/jbc.rev120.008745
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Moraes TF
中科院分区：
文献类型：
--
作者：
Cole GB;Bateman TJ;Moraes TF
革兰氏阴性病原体被一层外膜包裹着，这是一把双刃剑：一方面，它为细菌提供了一层保护，使其免受环境的侵害，包括其他细菌和宿主的免疫系统。另一方面，它限制了重要营养物质进入细胞的运动，并提供了大量可以被宿主免疫系统检测到的抗原。克服这些限制的一种策略是将革兰氏阴性细菌外表面的蛋白质通过脂质锚定拴在外膜上进行装饰。这些表面脂蛋白（slp）在免疫逃避和营养获取中发挥着关键作用，但随着越来越多的细菌基因组测序，我们开始发现它们的普遍存在及其不同的作用和机制，以及重要的是我们如何利用它们作为抗菌靶点。本文将重点介绍革兰氏阴性菌用于克服宿主先天免疫的代表性SLPs，特别是营养免疫和补体系统逃避。我们详细阐述了结合宿主靶分子所需的一些著名slp的结构，以及如何将这些信息与生物信息学一起用于理解结合机制和发现新的slp。这一信息为治疗方法的发展和疫苗抗原的设计提供了基础。
Gram-negative pathogens are enveloped by an outer membrane that serves as a double-edged sword: On the one hand, it provides a layer of protection for the bacterium from environmental insults, including other bacteria and the host immune system. On the other hand, it restricts movement of vital nutrients into the cell and provides a plethora of antigens that can be detected by host immune systems. One strategy used to overcome these limitations is the decoration of the outer surface of gram-negative bacteria with proteins tethered to the outer membrane through a lipid anchor. These surface lipoproteins (SLPs) fulfill critical roles in immune evasion and nutrient acquisition, but as more bacterial genomes are sequenced, we are beginning to discover their prevalence and their different roles and mechanisms and importantly how we can exploit them as antimicrobial targets. This review will focus on representative SLPs that gram-negative bacteria use to overcome host innate immunity, specifically the areas of nutritional immunity and complement system evasion. We elaborate on the structures of some notable SLPs required for binding target molecules in hosts and how this information can be used alongside bioinformatics to understand mechanisms of binding and in the discovery of new SLPs. This information provides a foundation for the development of therapeutics and the design of vaccine antigens.
影响因子：
2.9
作者：
Paek, Seonghee;Kawai, Fumihiro;Choi, Kyoung-Jae;Yeo, Hye-Jeong
通讯作者：
Yeo, Hye-Jeong